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When an ANA is positive and lupus is being considered, the subserologies help add clarity. Anti–double-stranded DNA (anti-dsDNA) and anti-Smith (anti-Sm) antibodies are the most specific for lupus and can support the diagnosis, with anti-dsDNA often reflecting disease activity. Anti-ds-DNA antibodies can also correlate with kidney involvement. Anti-Ro (SSA) and anti-La (SSB) are associated with lupus and Sjögren’s and can be linked to photosensitive rashes and other systemic features. Anti-RNP m
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