Protoporphyrin IX molecule, rotating 3D model of porphyrin, looped video on a black background
0:15
Protoporphyrin IX molecule, rotating 3D model of porphyrin, looped video on a black background
Feb 26, 2024
AdobeСергей Шиманович
Zinc Protoporphyrin Formation When iron levels are low, the body’s attempt to continue hemoglobin production leads to an interesting substitution: - The enzyme ferrochelatase, which normally inserts iron into protoporphyrin IX to form heme, instead incorporates zinc. - This results in the formation of zinc protoporphyrin (ZPP) instead of heme. The presence of increased ZPP has several important implications: - ZPP cannot function as hemoglobin, as it lacks the oxygen-carrying capacity of iron-ba
0:24
Zinc Protoporphyrin Formation When iron levels are low, the body’s attempt to continue hemoglobin production leads to an interesting substitution: - The enzyme ferrochelatase, which normally inserts iron into protoporphyrin IX to form heme, instead incorporates zinc. - This results in the formation of zinc protoporphyrin (ZPP) instead of heme. The presence of increased ZPP has several important implications: - ZPP cannot function as hemoglobin, as it lacks the oxygen-carrying capacity of iron-ba
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Kris Kinar lived with Erythropoietic protoporphyria (EPP), a rare sun-sensitivity disorder causing immediate severe pain upon sun exposure, for decades undiagnosed in sunny Saskatoon. Forced to remain indoors, he sought rare disease organizations, leading him to a clinical trial at Massachusetts General Brigham. There, he met Dr. Amy Yeung, an attending physician at Massachusetts General Hospital and Harvard Medical School assistant professor who also has EPP. The trial drug, Bitopertin, decreas
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Kris Kinar lived with Erythropoietic protoporphyria (EPP), a rare sun-sensitivity disorder causing immediate severe pain upon sun exposure, for decades undiagnosed in sunny Saskatoon. Forced to remain indoors, he sought rare disease organizations, leading him to a clinical trial at Massachusetts General Brigham. There, he met Dr. Amy Yeung, an attending physician at Massachusetts General Hospital and Harvard Medical School assistant professor who also has EPP. The trial drug, Bitopertin, decreas
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