Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. [1][2] They also respond to instances of …

May 4, 2025 · The current review highlights the different roles and regulatory mechanisms of HIF-1α and HIF-2α isoforms, focusing on their involvement in cell metabolism and the multi-step …

Hypoxia-inducible factor 1α (HIF-1α) is a subunit of the HIF-1 transcription factor which is encoded by the HIF1A gene. This transcription factor is the main modulator of the cell …

Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreased oxygen level in the cellular environment. Various isoforms and splice variants have been identified and their …

Jul 20, 2025 · Hypoxia-Inducible Factor, or HIF, is a group of proteins that functions as a master switch within our cells, responding to the availability of oxygen. This system allows organisms …

Dec 20, 2023 · Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …

Jan 18, 2025 · In this review, we describe an overview of the structure, expression, and DNA binding of the HIF-1 and HIF-2 complexes. We use the terminology ‘canonical’ to describe …

HIF-1 is the only transcription factor that has been found to be active under hypoxia, and is also the main nuclear transcription factor that mediates the adaptive response to hypoxia in …

HIF-1 and HIF-2 are the most extensively studied HIF transcription factors and facilitate oxygen delivery and adaptation to hypoxia by regulating a wide spectrum of cellular and tissue hypoxia …

Apr 21, 2022 · Hypoxia-inducible factors (HIFs) were discovered as activators of erythropoietin gene transcription in response to reduced oxygen (O 2) availability. O 2 -dependent …