In the end, this study extends our biological understanding of plasma proteins of DBT and generates hypotheses that may serve as the basis for future clinical trials toward the response …

Jul 7, 2021 · For the first time, we observed the immediate changes in lipid metabolism-related protein (CD36, LDLR, and PCSK9) before and after DFPP treatment in PBMCs, as well as the …

Mar 14, 2022 · This systematic review and meta-analysis examines the association between absolute reductions in low-density lipoprotein cholesterol levels with treatment

Nov 22, 2013 · We have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL …

Ablation of PK stabilizes LDLR, decreases LDL cholesterol, and prevents atherosclerotic plaque development. This study suggests that PK is a promising therapeutic target to treat …

Eukaryotic cells maintain a gradient in sterol concentration between plasma membrane (PM) and the membranes of cell organelles such as endoplasmic reticulum (ER) by both vesicular and …

Sep 2, 2024 · The overall aim of this thesis was to further characterize the regulation of cholesterol and bile acid metabolism in relation to plasma lipoproteins. Bile acid synthesis is …

Mar 8, 2021 · FGF21 improves hypercholesterolaemia by accelerating triglyceride-rich lipoprotein turnover as a result of activating BAT and browning of WAT, thereby reducing atherosclerotic …

Jul 4, 2025 · To investigate cholesterol-responsive networks, we performed integrated transcriptome (RNA-seq) and metabolome (LC-MS) analyses on HeLa cells treated with …

Mar 30, 2023 · Section 2 will describe how a PI (4,5)P 2 phosphatase, transmembrane protein 55B (TMEM55B), impacts circulating LDLc levels through its ability to regulate lysosomal …