Both Gclc and Gclm are characteristic NRF2 target genes, which establish NRF2 as a regulator of glutathione, one of the most important antioxidants in the body.

Jul 6, 2020 · Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of …

Mar 4, 2025 · Over the last 30 years, NRF2 has evolved from being recognized as a transcription factor primarily involved in redox balance and detoxification to a well-appreciated master …

Jul 24, 2025 · Nrf2 (Nuclear factor erythroid 2-related factor 2) is a protein in the human body that plays a significant role in cellular defense. It acts as a sensor, detecting various forms of stress …

Explore the NRF2 pathway's critical role in oxidative stress, inflammation, and chronic disease. Learn how NRF2 activation supports neuroprotection, cardiovascular health, and metabolic …

Canonical Nrf2 activation refers to oxidation or electrophilic modification of the cysteine of KEAP1, resulting in conformational changes in the KEAP1–Nrf2 complex that prevent degradation of …

Jul 12, 2024 · Nrf2, a key cellular regulator, plays a complex and multifaceted role in both protecting healthy cells and potentially promoting disease progression.

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in …

Sep 29, 2021 · Nrf2 is present in an inactive state in the cytoplasm of cells. Its activation by internal or external stimuli, such as infections or pollution, leads to the transcription of more …

Apr 21, 2025 · Nuclear factor erythroid 2-related factor 2 (NRF2) is a key transcription factor involved in regulating cellular antioxidant defense and detoxification mechanisms.