This paper reports a valuable discovery that specific-mode electroacupuncture (EA) transiently opens the blood-brain barrier (BBB) in rats. The evidence is solid but lacks functional validation of BBB ...

Here, we define a requirement for neural activity in mobilizing the antioxidant defenses of the nematode Caenorhabditis elegans both during chronic oxidative stress and prior to its onset. We show ...

Researchers have identified SLC45A4 as a neuronal polyamine transporter genetically linked to human chronic pain. Loss of this gene in mice disrupts polyamine balance, alters spinal GABA levels, and ...

Background Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome involving dysfunction of multiple immune cell ...

Despite significant advancements in medicine, cancer remains a major health challenge and the leading cause of mortality ...

Differential gene expression analysis demonstrated marked upregulation of multiple genes involved in immune activation, including the human leukocyte antigen, HLA-DQB1, co-stimulatory immune ...

Differential gene expression analysis was conducted using stringent criteria (|log2FC| > 1.3, P Results: Our analysis identified 10 commonly dysregulated genes across both datasets, forming a highly ...

Differential gene expression analysis identified commonly dysregulated genes in both conditions. Gene Ontology (GO) and KEGG pathway enrichment analyses were performed to understand the biological ...

Subsequent differential gene expression analysis, immune infiltration analysis, and univariate COX regression analysis further identified 54 EIGs. 101 combinations of 10 machine learning algorithms ...

Differential gene expression was determined, and pathway and gene enrichment analyses were performed on differentially expressed genes.Results L-Sep treatment induced differential gene expression ...