With Neymar Jr.'s return to Santos FC, the Brazilian club is now aiming to challenge the top teams in Brazil. To bolster their squad, they have secured the signing of an Argentine player who was a former rival of Lionel Messi’s Inter Miami in Major League Soccer.

Lionel Messi is expected to play as Inter Miami faces Sporting San Miguelito in Panama City, Panama at 5 p.m. ET. Here's what you need to know.

The preseason match, which kicks off at 5 p.m., is the third in the club’s Americas Tour, which also includes a game against Olimpia in Honduras next Saturday. Miami won its first two preseason games in penalty kick shootouts against Mexican team Club America and Universitario of Peru.

Football great Lionel Messi's eldest son, Thiago, has forced the world to take note of his talent with a spectacular performance in the U-13 Major League Soccer tournament.

Lionel Messi has appeared strong and in prime form in Inter Miami’s first two preseason games of the year. He's expected to play Sunday in Panama.

Inter Miami, with goals from Cremaschi, Allende, and Picault, defeated Sporting San Miguelito 1-3 on Sunday in an international friendly match that marked the return of Argentine Lionel Messi to Panama,

Inter Miami secured their first victory of the 2025 MLS preseason in their 1–3 win against Sporting San Miguelito.