Naloxone can reverse an overdose in minutes, but exactly how it does this at the molecular level has previously been unclear.

Scientists have visualized for the first time how opioids such as loperamide and the antidote naloxone engage a key brain receptor, offering insight that could lead to better pain treatments.

Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid (pronounced "mew-opioid") receptors. What they didn't know - until now - was ...

Chronic pain is a daily reality for millions of Americans, interfering with their everyday activities and quality of life. An ...

Listening to a favorite song can trigger a profound emotional response that rivals the feelings produced by biological ...

By comparison, typically antidepressants like SSRIs work by slowly adjusting serotonin levels and often take weeks to show ...

Oral presentation highlights the first time it's been demonstrated that the DOR is expressed on tumor-associated MDSCs, and that DOR inhibition reprograms multiple mechanisms of MDSC- induced ...