How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA ...

In medicine and biotechnology, the ability to evolve proteins with new or improved functions is crucial, but current methods are often ...

Researchers have discovered Sukunaarchaeum mirabile, a unique microbe found off the coast of Japan. This organism blurs the line between living cells and viruses. It possesses genes for protein ...

The invention of CRISPR and DNA sequencing has provided the necessary tools for rapidly engineering CHO cells along with a parts list.

Targeted rewriting of the epigenome promises to overcome several challenges in direct gene editing in patient therapies.

How chromatin responds to transcription-blocking DNA lesions is unclear. This study reveals that RNA polymerase II (RNAPII) ...

Unexpected slowdowns or spikes in this signal were often interpreted as knots in DNA. But now, a new study published Aug. 12 ...

What happens on the atomic scale when DNA transcription is paused has been unveiled for the first time.

Hypoxia-inducible factors (HIFs), ETS-1, MYC, and β-catenin act as master regulators that constitutively activate oncogenic ...

A detailed picture of what happens when DNA transcription is paused early in the process has been obtained by structural biologists at RIKEN. This could inform the development of new therapies.

Background Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome involving dysfunction of multiple immune cell ...