How chromatin responds to transcription-blocking DNA lesions is unclear. This study reveals that RNA polymerase II (RNAPII) ...

CGGBP1 binds to short CGG repeats in gene promoters, recruiting RNA:DNA helicases like DDX41 to ensure proper transcription ...

What happens on the atomic scale when DNA transcription is paused has been unveiled for the first time.

DNA’s chemical cousin, RNA, was the messenger that carries DNA instructions from the double helix in the cell’s nucleus to ...

In 1957, just four years after Francis Crick and other scientists solved the riddle of DNA’s structure—the now famous double ...

Pressing pause on DNA transcription What happens on the atomic scale when DNA transcription is paused has been unveiled for the first time Figure 1: An illustration showing RNA polymerase II (silver ...

Unexpected slowdowns or spikes in this signal were often interpreted as knots in DNA. But now, a new study published Aug. 12 ...

A detailed picture of what happens when DNA transcription is paused early in the process has been obtained by structural biologists at RIKEN. This could inform the development of new therapies.

Hypoxia-inducible factors (HIFs), ETS-1, MYC, and β-catenin act as master regulators that constitutively activate oncogenic ...

New genetic research suggests that hibernating animals' superpowers could lie hidden in our own DNA—and provides clues on how to unlock them, opening the door to someday developing treatments ...