Watching mainstream science in America under attack by the US federal and many state governments, most scientists and health ...

From the Human Genome Project to large-scale initiatives like the UK Biobank and The Cancer Genome Atlas (TCGA), the recent ...

The epithelial–mesenchymal transition (EMT) is a source of cancer cell plasticity and tumour heterogeneity, and is ...

For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

image image The study demonstrates that fibroblast growth factors suppress the cellular interferon response and thereby promote viral replication. Inhibition of FGF signaling has the opposite effect, ...

During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...

Human microproteins encoded by long non‐coding RNAs (lncRNA) have been increasingly discovered, however, complete functional characterization of these emerging proteins is scattered. Here, we show ...

The necrosome is the key macromolecular signaling platform initiating necroptosis, i.e., a RIPK1/RIPK3-dependent program of cell death with an important role in the control of inflammation in ...

Genome‐, transcriptome‐ and proteome‐wide measurements provide insights into how biological systems are regulated. However, fundamental aspects relating to which human proteins exist, where they are ...

Gpx4 and TRF are PPARα target genes involved in ferroptosis regulation. Loss of PPARα aggravates iron overload‐induced ferroptosis in vivo, while activation of PPARα is sufficient to largely alleviate ...

Only about 5 years after the first preclinical proof of concept for gene therapy of otoferlin-related auditory synaptopathy (Al-Moyed et al, 2018; Akil et al, 2019), preliminary reports from several ...

1 Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China 2 The Shanghai Key Laboratory of Medical Epigenetics, The International Co‐laboratory of Medical Epigenetics and ...