Basic research, often termed fundamental, frontier, blue-sky, curiosity-driven—or even useless—is the pursuit of knowledge for its own sake, unshackled by immediate practical applications (Flexner, ...

Several recent studies show that the E3 ligase RNF114 recognises a hybrid ADP-ribose-ubiquitin modification on substrate ...

Understanding temporal dynamics in tissue biology is key to linking transcriptomic snapshots to physiological function. Barkai et al. propose a turnover score derived from gene expression of shed ...

Previous studies have already established AP’s ability to arrest liver-stage development in the rodent malaria model, P.

This cover highlights the article Programmed cell revival from imminent cell death enhances tissue repair and regeneration by Kollori Dhar, Kautilya Kumar Jena, Santosh Chauhan and colleagues. The ...

Paxillin, long known as a cytoplasmic scaffold protein involved in cell adhesion and migration, emerges in a new role as a nuclear regulator of alternative splicing in developing neurons. In this ...

Mitochondria are cellular organelles involved in host‐cell metabolic processes and the control of programmed cell death. A direct link between mitochondria and innate immune signalling was first ...

Many compounds being considered as candidates for advanced biofuels are toxic to microorganisms. This introduces an undesirable trade‐off when engineering metabolic pathways for biofuel production ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Autophagy is responsible for clearance of an ...

Current understandings on cell motility and directionality rely heavily on accumulated investigations of the adhesion–actin cytoskeleton–actomyosin contractility cycles, while microtubules have been ...

Under normal conditions, SR proteins are hyperphosphorylated at their intrinsically disordered regions containing SR and SP dipeptides. Upon heat shock, SR proteins are rapidly dephosphorylated.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. It remained unknown how the ubiquitin ligase ...