As awareness about dementia continues to grow worldwide, a spate of online courses aims to help both health professionals and the general public understand Alzheimer’s and related diseases. Below is a ...

What makes synapses disappear with age? In the January 21 Nature, scientists led by Tony Wyss-Coray at Stanford University School of Medicine, California, report that sluggish turnover of synaptic ...

Progranulin is an obvious target for a frontotemporal dementia therapy, as up to 15 percent of cases arise from loss-of-function mutations in its gene, GRN. In a study published January 7 in Science ...

According to a recent study, the view that Alzheimer’s disease damages the brain irreversibly might need to change. In December 22 Cell Reports Medicine online, scientists led by Andrew Pieper of Case ...

As the brain’s fluid drainage systems become sluggish with age, troublemakers such as amyloid and tau aggregates start to build up. To flush out disease-causing detritus, neurosurgeons in China have ...

Professional Information Dr.McGill University Comments In TDP-43 Proteinopathy, Misplaced PolyA Tails Mean Crippled Retromers 13 Jan 2026 ...

This approach uses mesenchymal stem cells isolated from a patient’s own fat tissue to treat neurodegenerative diseases. The stem cells are supposed to assist in repair of damaged tissue and ...

These parkin knockout (KO) mice were generated by creating a germline disruption in the parkin gene within exon 3 leading to a truncated transcript coding for the first 95 amino acids of mouse parkin ...

A community cohort boasting 16,000 participants? A memory clinic that sees more than 2,000 patients per month? A countrywide goal of screening 80 percent of its aged population for AD? These are a few ...

The App SAA mouse joins a list of knock-in models that carry a humanized Aβ sequence within the murine App gene (App knock-in (humanized Aβ), APP NL-F Knock-in, APP NL-G-F Knock-in). As in the latter ...

Summary Two lines of transgenic mice that overexpress PSEN1 with the M146V mutation were developed simulataneously (line 8.2 and line 8.9) (Duff et al., 1996). Both lines have been crossed to Tg2576 ...

Notice of early expiration of PAR-24-213 NINDS Alzheimer’s Disease-Related Dementias (ADRD) Advanced Postdoctoral Career Transition Award (K99/R00 Independent Clinical Trial Not Allowed). The last ...