Hypoxia-inducible factors (HIFs), ETS-1, MYC, and β-catenin act as master regulators that constitutively activate oncogenic ...

Novel 3D analysis reveals core tumor niches drive resistance through AP-1 signaling and stromal reprogramming.

For years, scientists have considered transcription factors to be undruggable, but new research published this month in Molecular Cell shows they may be druggable after all (2024, DOI: 10.1016/j ...

Sustained hypoxia affects orthodontic tooth movement (OTM) by altering osteoclast and osteoblast differentiation, report ...

Researchers mapped 408 genes linked to frailty, revealing distinct biological aging patterns and possible personalized care ...

Jie Dong, Ning Sun, Jing Yang, Zhaoguo Deng, Jingqiu Lan, Genji Qin, Hang He, Xing Wang Deng, Vivian F. Irish, Haodong Chen, Ning Wei, The Transcription Factors TCP4 and PIF3 Antagonistically Regulate ...

A detailed picture of what happens when DNA transcription is paused early in the process has been obtained by structural ...