RNA-binding proteins use a dual binding mechanism involving zinc finger (ZnF) domains and intrinsically disordered regions ...

No. 10,000,772, which was issued in June 2018, and covers methods of using optimized guide RNA formats (including single-guide and dual-guide formats) in certain environments, including eukaryotic ...

RNA interference (RNAi) is a natural mechanism for controlling gene expression. 1 It is also commonly referred to as post-transcriptional gene silencing (PTGS). 2 Common to plants, animals, fungi, and ...

As aging progresses, the quality of DNA and proteins inside cells declines, which is known to be the cause of various ...

More information: Matteo Iannacone et al, Targeting HBV with RNA interference: Paths to cure, Science Translational Medicine (2025). DOI: 10.1126/scitranslmed.adv3678 ...

Journal Reference Santos-Aledo, A., et al. (2025). Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions. Nature Communications.