RNA-binding proteins use a dual binding mechanism involving zinc finger (ZnF) domains and intrinsically disordered regions ...

Bethesda, MD - Scientists have discovered a DNA sequence that is involved in controlling the timing of DNA replication. Because alterations in DNA replication timing are associated with cancer ...

Mistakes made during DNA replication can lead to mutations—permanent alterations in the DNA sequence that can have varying effects on the organism, ranging from benign to harmful.

DNA fragility can happen near other sequences that make the DNA form branched twists. Genomic analysis could reveal more mutation hotspots that lead to cancer, or the accumulation of repair errors ...

The findings lead scientists to believe that repetitive DNA sequences could trigger a damage response signal indicating that errors in DNA replication have occurred and require repair. DNA damage ...

The findings lead scientists to believe that repetitive DNA sequences could trigger a damage response signal indicating that errors in DNA replication have occurred and require repair.

CRISPR-Cas9 works by excising specific DNA sequences using a gene-cutting protein, Cas9, sourced from bacterial immune systems. Shepherded by a gene-targeting RNA, the protein snips out bits of code.

Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis. Nature, 2023; DOI: 10.1038/s41586-023-06327-7 ...

To date, people have encoded information into DNA the same way nature has, by linking the four nucleotide bases comprising DNA—A, T, C, and G—into a particular genetic sequence.