DNA-PKcs, which is typically thought to only be recruited to sites of DNA breaks, is also present at ongoing replication forks. We see this as normal replication is occurring, indicating the DNA ...

Then they used a DNA fiber assay with fluorescent colors, such that the faster the replication forks moved, the longer the fibers became. In the presence of chemotherapy drugs, the fibers were ...

Then they used a DNA fiber assay with fluorescent colors, such that the faster the replication forks moved, the longer the fibers became. In the presence of chemotherapy drugs, the fibers were ...

New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...

Embryonic stem cells maintain high origin activity and slow forks to coordinate replication with cell cycle progression. EMBO Reports, 2024; DOI: 10.1038/s44319-024-00207-5 ...

BUFFALO, N.Y. – New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no ...

More information: Bruce Stillman et al, Mechanisms for licensing origins of DNA replication in eukaryotic cells, Nature Structural & Molecular Biology (2025). DOI: 10.1038/s41594-025-01587-5 ...