RNA splicing requires specific sequences in the pre-mRNA that mark where introns and exons are located. Occasionally, mutations in these sequences can lead to the production of mRNAs that are out ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms.

From Johns Hopkins University School of Medicine, Charlotte J. Sumner, M.D., presents an editorial on a study by Richard S.

A new discovery about mutations in a gene that causes ALS may allow researchers to design targeted therapies, a study found.

One such nuclear body, the speckle, contains spliceosomes that are known to be involved in mRNA splicing. Disruption of speckles leads to a range of diseases and developmental disorders, yet how ...

Splicing is closely linked with transcription, involving a dynamic interaction between the mRNA, RNA polymerase II (Pol II), and chromatin structures. 5 “There's strong evidence that splicing of ...

Researchers identified messenger RNA that is missing in pediatric high-grade glioma tumors but not in normal brain tissues.

A new study, led by researchers at Children's Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that ...

Risdiplam is a centrally and peripherally distributed oral SMN2 pre-mRNA splicing modifier that increases and sustains functional SMN protein levels. 4-6 The safety and efficacy of risdiplam have ...