“With detailed process comprehension of the IVT fundamentals, the conditions for the operation of continuous in vitro transcription could be optimized in this work to produce 55% more mRNA with ...

In this experiment, they ran the TFF at a capacity load of ∼19 g/m 2, less than 2.5 psi trans-membrane pressure, and feed flux of 300 L/m 2 /h (LMH), corresponding to a shear rate of 1594 s −1 ...

Unlocking the potential of mRNA technology is helping revolutionize medicine and biotechnology. Solid-phase in vitro transcription enables scalability and automation, helping make it a valuable tool ...

The discovery of chemical modifications to overcome mRNA’s instability and immunotoxicity have enabled mRNA therapeutics to evolve dramatically, reaching clinical trials and the forefront of ...

A detailed picture of what happens when DNA transcription is paused early in the process has been obtained by structural ...

Bhuiyan et al. TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing factors. Cell Reports, Vol. 44, Issue 5, 2025. DOI: 10.1016/j.celrep.2025.115616 Contact ...