The Wnt signalling pathway governs key processes in embryonic development, tissue homeostasis and stem cell maintenance by regulating gene expression through β-catenin–dependent and ...

Researchers have described a large set of previously unrecognized enzymatic domains—named the Lipocone superfamily—and outlined their evolutionary pathway from bacterial defense molecules to key ...

Targeting the WNT signaling pathway represents a promising strategy for cancer therapy. The field has evolved to include numerous inhibitors currently under preclinical and clinical investigation.

Signal transduction The cellular process that converts a signal, such as a hormone, growth factor, neurotransmitter, cytokine, mechanical force, or environmental cue, into biochemical changes inside ...