Hepatitis D virus hijacks host cell transcription machinery to make copies of its genetic code. Here, we take a look at the steps involved in this process.

Later in infection, Ebola virus polymerase gains a foothold in cells by hijacking a subset of cellular proteins from the host antiviral defense line to promote viral replication.

The hierarchical contribution of causal pathways of chronicity and immunopathogenesis is poorly understood. 7 Persistent viral replication cannot be contained by the depleted and defective HBV ...

This study reports two cryo-EM structures of the Nipah virus (NiV) polymerase L-P complex in its full-length and truncated forms. These structures elucidate the RNA-dependent RNA polymerase (RdRp ...

During viral reproduction, the influenza polymerase (top left, in blue) scans along the ribonucleoprotein helix to produce messenger RNA. Credit: Science Like a camera-shy teenager, influenza’s ...

Using cryo-microscopy, researchers present a high-resolution structure of monkeypox virus DNA polymerase holoenzyme, a complex that plays a key role in the genome replication process of the virus.

SARS-CoV-2 proteins are like Swiss army knives. They have many functions. Here we describe one of the proteins that attracts most interest, the viral polymerase, the target of several antiviral ...

The monkeypox virus has its own DNA polymerase F8 which, when together with the processive cofactors A22 and E4, constitutes the polymerase holoenzyme for genome replication.

Herpesviruses encode their own DNA replication machinery. KSHV expresses six DNA replication proteins: DNA polymerase (ORF9), polymerase accessory factor (ORF59), helicase (ORF44), primase (ORF56), ...

Cryo-EM structures reveal how the DNA polymerase of herpes simplex virus interacts with DNA and antiviral drugs.