Our cells produce a variety of proteins, each with a specific role that, in many cases, means that they need to be in a ...

The concept of transcription and translation opposing each other to restrain tumor formation was so novel that Jana had to give this phenomenon a name: transcriptional-translational conflict.

Hypoxia-inducible factors (HIFs), ETS-1, MYC, and β-catenin act as master regulators that constitutively activate oncogenic ...

Cryptic transcription by senescent cells was first observed in yeast and worms and later confirmed in mammalian cells. While its function, especially in mammalian cells, has yet to be fully ...

Through transcription and translation, cells can read the genetic information from the DNA and produce the amino acids that make up proteins.

Young cells have mechanisms in place to prevent cryptic transcription. In aged mammalian cells, the researchers found that one such mechanisms, which involves limiting the access to chromatin, the ...

Researchers from the A*STAR Institute of Molecular and Cell Biology (IMCB) have identified Nr1h2, a critical transcription factor essential for early embryo development. Published in Nature ...

Researchers describe six subsets of memory B cells — including one subset that produces the transcription factor T-bet. Using detailed genetic analysis and manipulation, they show that ...

Researchers have discovered that a cellular phenomenon called cryptic transcription, which had been previously described and linked to aging in yeasts and worms, is also involved in mammalian ...

Nr1h2: A key transcription factor unlocks new potential in stem cell-based embryo models Date: December 9, 2024 Source: Agency for Science, Technology and Research (A*STAR), Singapore Summary ...