Alltrna's ML-driven platform optimizes sequence and modifications from natural tRNAs to significantly increase premature termination codon (PTC) readthrough First Alltrna-engineered tRNA ...

About Stop Codon Disease Stop Codon Disease encompasses thousands of rare and common diseases that stem from premature termination codons (PTC) also called nonsense mutations, where the code for ...

The Alltrna tRNAs not only read premature termination codon mutations, they also restored protein production. In vitro testing using human-derived cells and in vivo testing in an animal model of a ...

Our plan is to engineer modified tRNAs that are specifically designed to read through these premature termination codon mutations.

A conserved opal termination codon optimizes a temperature-dependent trade-off between protein production and processing in alphaviruses. Science Advances, 11 (16), eads7933.