The high pressure led to an increased population of the tRNA-excited states that normally exist at very low levels, allowing new insights into tRNA function.

Without the gene, known as DDX1, certain transfer RNA can no longer bring amino acids to the ribosome to make new proteins. If the cells can't process these tRNAs properly, then the ribosomes can ...

A study conducted by a research team from Kumamoto University has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the ...

A groundbreaking study has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the absence of TRMT10A leads to a reduction ...

Inosine forms two hydrogen bonds with adenine, similar to the Watson-Crick base pairing between adenine and uracil. However, inosine can also form wobble base pairs with cytosine and uracil, although ...

Each transfer RNA molecule transports a specific amino acid to the ribosome — a cell structure that strings amino acids together to form proteins, based on the instructions carried by messenger RNA.

Like mRNAs, tRNAs need to be spliced to function. In their papers, the two groups showed that mutations in a particular kinase in the splicing pathway interfere with tRNA processing, resulting in a ...