Unexpected slowdowns or spikes in this signal were often interpreted as knots in DNA. But now, a new study published Aug. 12 ...

DNA gyrase operates like a tiny molecular machine, carefully twisting and stabilising bacterial DNA. This twisting, known as supercoiling, is similar to winding an elastic band: as it twists, it ...

This enzyme, present in bacteria but absent in humans, plays a crucial role in supercoiling DNA, a necessary process for bacterial survival.

DNA minicircles and advanced imaging techniques reveal first step to untangle DNA We typically picture DNA as the straight double helix structure, but inside cells, DNA exists in supercoiled loops.

It is present in bacteria but absent in humans and plays a crucial role in supercoiling DNA, a necessary process for bacterial survival.

He and his team demonstrated in a recent study published in Molecular Cell that negatively supercoiled DNA conformations increase off-target Cas9 effects. 1 These findings highlight important ...

Additionally, they make clear that DNA looping also affects the supercoiling state of our chromosomes, which directly affects processes like gene expression.

This enzyme, present in bacteria but absent in humans, plays a crucial role in supercoiling DNA, a necessary process for bacterial survival.