Researchers have used artificial intelligence to design ionizable lipids that outperform current gold-standard molecules in delivering mRNA, a key technology in vaccines and gene therapies. The ...

A new computational study led by University at Buffalo scientists and published April 21 in Biophysical Journal sheds light ...

Lipids are a class of biomolecules that play an important role in many cellular processes. Analyses that seek to characterize all lipids in a sample—called lipidomics—are crucial to studying complex ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction, which the ...

Membrane proteins and membrane lipids are essential partners in various biological processes, and elucidating their structures in a natural membrane environment is crucial for enhancing our ...

Lipid nanoparticles address key drug delivery challenges, including immune evasion, toxicity, and regulatory approval.