Pre-mRNA trans -splicing goes a step further still, using the spliceosome to match up an endogenous pre-mRNA, encoding a target protein, with an exogenous RNA, encoding a portion of that same ...

From Johns Hopkins University School of Medicine, Charlotte J. Sumner, M.D., presents an editorial on a study by Richard S.

One such nuclear body, the speckle, contains spliceosomes that are known to be involved in mRNA splicing. Disruption of speckles leads to a range of diseases and developmental disorders, yet how ...

Building proteins RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

Transcription: During transcription, the enzyme RNA polymerase reads the DNA sequence of a gene and uses it as a template to synthesize a complementary strand of pre-mRNA. This pre-mRNA undergoes ...

Additionally, the study uncovered the molecular basis behind this phenomenon: without PP2A B′η, numerous genes fail to undergo proper RNA splicing, leading to the breakdown of essential protein ...