Humans have roughly 20 thousand genes within our genomes, but thanks to alternative splicing, cells can make many more proteins than the number of genes. This expanded catalogue of proteins helps ...

Cracking the Code, narrated by Mark Ruffalo, tells the inspiring story of Phil Sharp’s journey from Kentucky farm boy to Nobel laureate. His 1977 discovery of RNA splicing revolutionized molecular ...

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs - single-stranded RNAs involved in protein synthesis - and proteins from the same stretch of DNA ...

Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment. Nature Aging, 2022; DOI: 10.1038/s43587-022-00290-0 ...

The structure of a key enzyme involved in protein production is revealed by cryo-electron microscopy (cryo-EM). Using cryo-EM, researchers at Goethe University (Frankfurt, Germany) shed light on ...

Merck KGaA has swooped into a neurological-focused pact with RNA biotech Skyhawk Therapeutics that could top out at $2 ...

By identifying shared splicing neoantigens present in up to 90% of cancer patients, SNAF presents new therapeutic targets and expands understanding of cancer biology ...

It may be time to rethink certain genetic mutations associated with two devastating neurodegenerative disorders—amyotrophic ...