High-resolution structures of nascent polypeptide chains in complex with the ribosome — the cell’s protein-synthesis machinery — reveal how the ribosome guides protein folding. Ribosomal ...

The researchers wanted to find a way to watch this ribosome-assembly process play out. Everything begins with RNA produced in the nucleolus's innermost layer.

They also showed, for the first time, how ribosomes are arranged in neurons—research that could eventually be key to understanding what goes wrong in ribosomes during neurodegenerative diseases.