Gene expression and regulation describes the process by which information encoded in an organism's DNA directs the synthesis of end products, RNA or protein. The articles in this Subject space ...

Manipulating Gene Expression to Treat Disease Several of our scientists study gene regulation in specific cancers, including cancers of the blood, lung, pancreas and prostate. They seek treatment ...

Anindya Dutta, Ph.D. Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports. “This is ...

But surprisingly, say the UAB Marnix E. Heersink School of Medicine and University of Virginia School of Medicine researchers, ORC2 binding at many other sites activated chromatin for gene expression.

Thus PI 3-kinase is required for the regulation of PEPCK gene expression by insulin but not by phorbol esters. In liver cells, insulin administration stimulates the activity of multiple protein ...

The course explores gene regulation in eukaryotes from nuclear organisation to cytosolic control, with a focus on animals and humans. The molecular mechanisms of transcription within a chromatin ...

Researchers from the National University of Singapore (NUS) have revealed that diet and exercise can change gene regulation in the skeletal muscle of East Asians, highlighting the critical role of ...

But there is an additional layer of regulation that results from cell-to-cell interactions within the organism that orchestrate development. Specifically, gene expression is controlled on two levels.

DOI: 10.1016/j.celrep.2025.115816 Origin-recognition complex (ORC) plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports.