How chromatin responds to transcription-blocking DNA lesions is unclear. This study reveals that RNA polymerase II (RNAPII) ...

In 1957, just four years after Francis Crick and other scientists solved the riddle of DNA’s structure—the now famous double ...

DNA’s chemical cousin, RNA, was the messenger that carries DNA instructions from the double helix in the cell’s nucleus to ...

A detailed picture of what happens when DNA transcription is paused early in the process has been obtained by structural ...

CGGBP1 binds to short CGG repeats in gene promoters, recruiting RNA:DNA helicases like DDX41 to ensure proper transcription ...

Bhuiyan et al. TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing factors. Cell Reports, Vol. 44, Issue 5, 2025. DOI: 10.1016/j.celrep.2025.115616 Contact ...

Messenger RNA is a go-between molecule that copies DNA codes for building proteins — a process called transcription — and then delivers the transcripts to the cell’s many protein factories, which are ...

Hypoxia-inducible factors (HIFs), ETS-1, MYC, and β-catenin act as master regulators that constitutively activate oncogenic ...

In particular, it allows the state of RNA polymerase II known as the elongation complex to transform into a structure that allows for efficient transcription. Promoter-proximal pausing is important ...

A new nanotube-based RNA delivery system boosts plant regeneration by switching off a molecule that blocks shoot growth, ...