A detailed picture of what happens when DNA transcription is paused early in the process has been obtained by structural ...

DNA’s chemical cousin, RNA, was the messenger that carries DNA instructions from the double helix in the cell’s nucleus to ...

Hypoxia-inducible factors (HIFs), ETS-1, MYC, and β-catenin act as master regulators that constitutively activate oncogenic ...

In 1957, just four years after Francis Crick and other scientists solved the riddle of DNA’s structure—the now famous double ...

Once transcription is initiated, the DNA double helix unwinds and RNA polymerase reads the template strand, adding nucleotides to the 3′ end of the growing chain (Figure 2b).

However, transcription - and therefore cell differentiation - cannot occur without a class of proteins known as RNA polymerases. Understanding how RNA polymerases function is therefore fundamental ...

RNA synthesis, or transcription, is the process by which RNA is produced using DNA as a template. This process is carried out by the enzyme RNA polymerase, which binds to specific promoter regions on ...

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a ...

RNA has a similar chemical structure, but–unlike DNA–is usually single-stranded. It can copy segments of the DNA using a transcription process.

Evolution is a game of trade-offs. Every trait an organism inherits may have benefits and drawbacks; what matters to natural selection is whether the trait is positive or negative on balance. But in a ...

Blood glucose levels were only affected when the gene was deleted in β‑cells. HNF1A is a known transcription factor, meaning its job is to bind to DNA and fine-tune the expression of other genes.