A new study, led by researchers at Children's Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that ...

A research team led by Professor Wang Yangming from the Institute of Molecular Medicine, College of Future Technology, and the Beijing Advanced Center of RNA Biology (BEACON) at Peking University has ...

Weill Cornell Researchers Develop New Technique to Investigate Impact of Abnormal RNA Splicing on Disease By Science Department Sep 13, 2023 3:22 pm · Updated Sep 13, 2023 7:23 pm ...

While major splicing carries out 99.5% of this work, minor splicing is an indispensable process for the remaining 0.05% of genes, affecting about 700 of the 20,000 genes in the human genome.

Our study reveals that the ribosomal protein RPL22, typically a structural component of the ribosome, plays an unexpected dual role as a critical regulator of RNA splicing." ...

Conclusions To summarize, the study identified RNA splicing errors as a major source of tumor-specific neoantigens in gliomas, offering new opportunities for targeted immunotherapy.

Building proteins RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

While major splicing carries out 99.5% of this work, minor splicing is an indispensable process for the remaining 0.05% of genes, affecting about 700 of the 20,000 genes in the human genome.

Fred Hutch and MSK researchers showed that tumors driven by hiccups in RNA processing can't hid from the immune system. In work published in Cell, the team showed they could isolate T cells that ...

However, this RNA contains both essential and non-essential segments. To produce functional proteins, the unnecessary parts must be precisely removed in a process known as RNA splicing.

RNA splicingPost-transcriptional splicing has emerged as a key layer of gene expression regulation but is challenging to differentiate from co-transcriptional splicing. The authors review ...

RNA splicing involves the removal of non-coding introns and the joining of coding exons in precursor mRNA (pre-mRNA) to produce mature messenger RNA (mRNA). Splicing changes can lead to diseases ...