RNA-binding proteins use a dual binding mechanism involving zinc finger (ZnF) domains and intrinsically disordered regions ...

RNA sequencing (RNA-seq) is a powerful tool for molecular biologists looking for what drives mechanisms of disease. 1 RNA-seq is routinely used for both research and clinical applications in diseases ...

Rapid precision run-on sequencing (rPRO-seq) may help doctors understand disease states and treatment response in real time.

Long-read single-cell RNA sequencing enables the study of cancer subclone-specific genotypes and phenotypes in chronic lymphocytic leukemia. Genome Res (this issue) 35: 686–697. doi:10.1101/gr ...

In a study of the effects of spaceflight on human physiology, researchers from Weill Cornell Medicine and other institutions performed direct RNA-seq on samples collected from four astronauts at ...

But rPRO-seq reveals 'nascent' RNA – what's being made right now. It's like watching cars leave the factory. This gives us crucial, real-time insights into active gene transcription," said Cingaram.

Researchers at Baylor College of Medicine have tested the feasibility of using human cell transdifferentiation with RNA sequencing to facilitate diagnoses of Mendelian disorders. The approach ...

RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at ...

Among 103 samples with matched DNA sequencing, RNA-seq detected 93.3% of oncogenic variants. Variant allele frequencies between RNA-seq and DNA-seq showed strong correlations.

Gordon Sanghera, PhD, co-founder and CEO of Oxford Nanopore Technologies, holds one of his company’s MinION palm sized native DNA/ RNA sequencers in a 2023 video interview with the British ...