Schubert, S., Grunweller, A., Erdmann, V.A. & Kurreck, J. Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions.

This paper culminates years of research on the RNA secondary structure and its role in the regulation of gene expression. We have published an extensive computation-based catalog of potentially ...

The secondary structure of an RNA molecule plays an integral role in its maturation, regulation, and function. However, the global influence of this feature on plant gene expression is still largely ...

More information: Identification of conserved RNA regulatory switches in living cells using RNA secondary structure ensemble mapping and covariation analysis, Nature Biotechnology (2025).

Structural RNA has lower folding energy than random RNA of the same dinucleotide frequency. RNA, 11 (5):578-591 (2005). F. Ferre and P. Clote. Disulfide connectivity prediction using secondary ...

In addition to the standard Watson-Crick base pairs, there are also non-canonical base pairs that can form in certain situations. These include wobble base pairs, such as G-U and I-A (inosine -adenine ...