The second step of GMP-grade RNA production from the template is impeded by a slow, unreliable, and inefficient process in which only one therapy can be made per GMP suite.

While major splicing carries out 99.5% of this work, minor splicing is an indispensable process for the remaining 0.05% of genes, affecting about 700 of the 20,000 genes in the human genome.

Now, his team has discovered that two important regulator proteins work together to keep the splicing process on track. One of those regulators, a protein called SRSF1, has been a focus of Krainer ...

Bhuiyan et al. TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing factors. Cell Reports, Vol. 44, Issue 5, 2025. DOI: 10.1016/j.celrep.2025.115616 Contact ...

Now, researchers from Kyushu University have revealed that the smallest known protein-based tRNA-processing enzyme, called HARP, forms a star-shaped complex of 12 protein molecules, making it ...