RNA-binding proteins use a dual binding mechanism involving zinc finger (ZnF) domains and intrinsically disordered regions ...

Nano-tRNAseq is based on nanopore sequencing, a technology that can directly sequence individual RNA molecules by passing them through a small pore. Each of the nucleotides that compose an RNA ...

Now, his team has discovered that two important regulator proteins work together to keep the splicing process on track. One of those regulators, a protein called SRSF1, has been a focus of Krainer ...

Now, researchers from Kyushu University have revealed that the smallest known protein-based tRNA-processing enzyme, called HARP, forms a star-shaped complex of 12 protein molecules, making it ...

Bhuiyan et al. TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing factors. Cell Reports, Vol. 44, Issue 5, 2025. DOI: 10.1016/j.celrep.2025.115616 Contact ...

MicroRNAs (miRNAs) are tiny RNA molecules that regulate gene expression by controlling messenger RNAs (mRNAs) and are ...

While major splicing carries out 99.5% of this work, minor splicing is an indispensable process for the remaining 0.05% of genes, affecting about 700 of the 20,000 genes in the human genome.

A study from the Walter and Eliza Hall Institute of Medical Research (WEHI) has found that blocking a specialised RNA process called minor splicing slows tumour growth in animal models of liver, lung ...