In the first three cohorts, the participants received a subcutaneous injection of plozasiran (10 mg, 25 mg, or 50 mg) or placebo on day 1 and at week 12 (quarterly doses).

In a Phase 1 clinical trial for zilebesiran, Desai et. al found that a single injection of this RNA interference therapy reduced high blood pressure for up to 24 weeks.

RNA interference (RNAi) is a natural mechanism for controlling gene expression. 1 It is also commonly referred to as post-transcriptional gene silencing (PTGS). 2 Common to plants, animals, fungi, and ...

The term RNAi — short for RNA interference — crops up again and again in biology research these days. This is in part because of its power as a laboratory tool, and in part because it is a ...