In 2023, SpliceBio signed a licensing agreement with Spark Therapeutics, allowing the latter to use its protein splicing platform and develop a gene therapy for an undisclosed inherited renal disease.

Study describes a mechanism that extends the number of antigenic peptides that can be produced from a single protein.

Colinearity of DNA and protein sequences is thought to be a fundamental feature of the universal genetic code. However, a paper published today in Science by a team from the Brussels Branch of the ...

These two alternative splicing sites are different from the mutation-created novel intra-exonic 3′ splice site reported here.

During splicing, U4/U6.U5 normally ensures the immediate and correct re-joining of loose ends after a transcript has been cut. Without USP39, or when subunits are mutated, this re-joining is delayed.

New research from the University of Chicago suggests that alternative splicing may have an even greater influence on biology than just by creating new protein isoforms. The study, published this ...

When the researchers mutated the protein regions required for the interaction, the splicing abilities of RBM5 were disrupted when analyzed in a cell culture model. In a test tube, the mutated proteins ...

The researchers were able to identify protein misfolding as one cause and have developed a method to prevent it. The splicing of proteins rarely occurs in nature but is very interesting for research.

The RNA-binding protein Sam68 is involved in apoptosis, but its cellular mRNA targets and its mechanism of action remain unknown. We demon- strate that Sam68 binds the mRNA for Bcl-x and affects its ...