Protein splicing is a naturally occurring post‐translational process in which inteins, as self‐excising protein segments, precisely remove themselves from a host polypeptide and concomitantly ...

Dubbed the ‘guardian of the genome’, the p53 protein responds to DNA damage by stalling cell division, initiating DNA repair ...

A new discovery about mutations in a gene that causes ALS may allow researchers to design targeted therapies, a study found.

Protein trans-splicing of the wildtype Aes intein. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-57596-x ...

During splicing, U4/U6.U5 normally ensures the immediate and correct re-joining of loose ends after a transcript has been cut. Without USP39, or when subunits are mutated, this re-joining is delayed.

It may be time to rethink certain genetic mutations associated with two devastating neurodegenerative disorders—amyotrophic ...

To maintain constant protein production, they require highly precise splicing, a function that USP39 provides. "Blocking USP39 in these cancer cells could selectively kill them," Đikić explains.

RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.