Protein splicing is a naturally occurring post‐translational process in which inteins, as self‐excising protein segments, precisely remove themselves from a host polypeptide and concomitantly ...

During splicing, U4/U6.U5 normally ensures the immediate and correct re-joining of loose ends after a transcript has been cut. Without USP39, or when subunits are mutated, this re-joining is delayed.

To maintain constant protein production, they require highly precise splicing, a function that USP39 provides. "Blocking USP39 in these cancer cells could selectively kill them," Đikić explains.

RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

The researchers were able to identify protein misfolding as one cause and have developed a method to prevent it. The splicing of proteins rarely occurs in nature but is very interesting for research.

Protein trans-splicing of the wildtype Aes intein. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-57596-x ...

This is the first time that alternative splicing has been shown to play a functional role in the development of the most aggressive kind of medulloblastoma.” Importantly, the researchers discovered ...

Dubbed the ‘guardian of the genome’, the p53 protein responds to DNA damage by stalling cell division, initiating DNA repair ...

A new discovery about mutations in a gene that causes ALS may allow researchers to design targeted therapies, a study found.

During splicing, U4/U6.U5 normally ensures the immediate and correct re-joining of loose ends after a transcript has been cut. Without USP39, or when subunits are mutated, this re-joining is delayed.