This interplay between CMA-driven protein targeting and macroautophagy-mediated vesicle dynamics provides a novel mechanistic framework for the unconventional secretion of PARK7.

Bacillus subtilis has emerged as a pre‐eminent model organism for the study and application of protein expression and secretion, owing to its robust secretory pathways and genetic tractability ...

Export of protein molecules across the bacterial membranes takes place via a variety of mechanisms, from simple one-component systems to complex multicomponent pathways, with five types of ...

KZR-261, a novel, first-in-class protein secretion inhibitor, is the first clinical candidate to be nominated from Kezar’s research and discovery efforts targeting the protein secretion pathway.

The invention of CRISPR and DNA sequencing has provided the necessary tools for rapidly engineering CHO cells along with a parts list.

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells.

Two key proteins perform powerful functions on a major secretory pathway Researchers from The University of Osaka find the key proteins that maintain optimal pH within the Golgi apparatus by ...

About Inhibition of Protein Secretion Kezar’s drug discovery platform of protein secretion pathway inhibitors is a novel approach with broad application.

The findings indicate that ORF8 likely secretes from the classic endoplasmic reticulum/Golgi protein secretion pathway. ORF8 protein induces inflammatory response seen in SARS-CoV-2 infection ...

Researchers have identified how autophagy and chaperone-mediated autophagy (CMA) drive the unconventional secretion of PARK7, a protein linked to Parkinson's disease. Their findings suggest new ...