Perhaps no topic is hotter in Alzheimer disease molecular research today than the synaptic effects of amyloid-β (Aβ) oligomers. These toxic assemblies disrupt synaptic function, and are leading ...

Increasing the levels of a particular phospholipid in the membranes of brain cells may offer a promising new way to improve blood circulation in the brain and support healthier brain activity. A poten ...

PIP2 is an important phosphoinositide that is present in around 1% of the plasma membrane. It is also involved in signal transduction of intracellular and extracellular components. There are two ...

A preclinical study from the University of Vermont has linked excessive activity of the mechanosensor Piezo1 in brain blood ...

My research is focused on the role of chronic inflammation in cardiovascular disease (CVD) and lung cancer. Working at the Cleveland Clinic has been an excellent environment for testing my novel ...

Cells have certain proteins that help them adhere to each other while covering body surfaces and organs. Loss of these identifying proteins could result in cellular progression towards cancer and, ...

The regeneration of a signaling molecule, phosphatidylinositol 4,5 bisphosphate (PIP2), is not as simple as it was thought to be. Experimental work and mathematical modelling show that the decades-old ...

The effects of low root temperature on growth and root cell water transport were compared between wild-type Arabidopsis (Arabidopsis thaliana) and plants overexpressing plasma membrane intrinsic ...