Researchers used CRISPR gene editing to selectively kill cancer cells with amplified oncogenes. In animal and cellular models ...

The onset and aggressiveness of cancer are related to the abnormal behavior of certain genes, known as oncogenes. The ...

There are trillions of living cells in the body that grow, divide, and die in an orderly fashion. This process is tightly regulated by the genes within a cell’s nucleus. These genes code for proteins ...

As core components of spindle poles, centrosomes have a key role in directing the formation of bipolar mitotic spindles, which is crucial for accurate segregation of chromosomes during cytokinesis.

In cellular and animal models of neuroblastoma, small cell lung cancer and colon cancer, this strategy reduces tumours, ...

Recurrent genomic instability in cancer is attributed to positive selection and/or the sensitivity of specific genomic regions to breakage. Among these regions are fragile sites (FSs), genomic regions ...

In this scanning electron micrograph of inside the nucleus of a cancer cell, chromosomes are indicated by blue arrows and circular extrachromosomal DNA are indicated by orange arrows. [Paul Mischel, ...

The onset and aggressiveness of cancer are related to the abnormal behaviour of certain genes, known as oncogenes. The best-known of these alterations ...

Cancer is caused by alterations in oncogenes, tumor-suppressor genes, and microRNA genes. These alterations are usually somatic events, although germ-line mutations can predispose a person to ...

Although hypomethylating agents are currently used to treat patients with cancer, whether they can also reactivate and up-regulate oncogenes is not well elucidated. By combining analysis of patient ...

Your genes are made of sequences of DNA that contain the information necessary for your cells to function and grow properly. Genes contain instructions that tell a cell to make a specific type of ...