Leptin-deficient (ob/ob) mice are obese and infertile. Dysfunctions of the ovaries are preferentially related to leptin-deficiency. Morphological and molecular biological obesity-dependent changes ...

When a mouse catches a whiff of a cat or a rat, it cautiously steps away from the direction of the scent, generally backward so it can keep an eye on the predator. Then it stands on tiptoe, ears ...

That’s why sharing blood with a normal mouse helped. In 1994, 45 years after ob/ob was first discovered, scientists finally pinpointed the exact gene that made the mice obese.

But the discovery of the obese gene (ob gene) in 1994 by Jeffrey Friedman, a Howard Hughes Medical Institute investigator at Rockefeller University, has revolutionized the search for new therapies to ...

Below, the lungs of a wild-type mouse (left) and an Ob/Ob mouse (right) were observed with a two-photon microscope . Venus (green) visualizes infected cells, Ly-6G (red) visualizes neutrophils, ...