When a mouse catches a whiff of a cat or a rat, it cautiously steps away from the direction of the scent, generally backward so it can keep an eye on the predator. Then it stands on tiptoe, ears ...

That’s why sharing blood with a normal mouse helped. In 1994, 45 years after ob/ob was first discovered, scientists finally pinpointed the exact gene that made the mice obese.

But the discovery of the obese gene (ob gene) in 1994 by Jeffrey Friedman, a Howard Hughes Medical Institute investigator at Rockefeller University, has revolutionized the search for new therapies to ...

The ob/ob mouse is a well-accepted model of type 2 diabetes. Still, the animals differ from humans with type 2 diabetes in having a leptin deficiency and a very early emergence of pathology. This ...

Observer (OB) and demonstrator (DM) mice are placed in separate chambers and allowed to adapt to the new environment for 5 minutes. Soon afterward, the DM mouse shows pain and panic reactions due ...

Below, the lungs of a wild-type mouse (left) and an Ob/Ob mouse (right) were observed with a two-photon microscope . Venus (green) visualizes infected cells, Ly-6G (red) visualizes neutrophils, ...