Drosophila wing development is a paradigm for understanding how spatial information is conveyed by morphogen gradients to coordinate pattern formation and organ growth. Central to this process is ...

Cells producing noise in the Wnt morphogen gradient are sensed by neighboring cells through E-cadherin and then eliminated through the Smad-ROS (reactive oxygen species) axis. Disclaimer: AAAS and ...

In a recent study published in Nature Communications, researchers examinea the effects of temporal morphogen gradient during neural induction (NI) on the formation of brain organoids. Study: Temporal ...

The study revealed the small-molecule signaling system for mammalian cell-cell communication that combines super-sensitivity with a chassis-friendly, low-burden design, and demonstrated the system's ...

Human neural organoids, derived from pluripotent stem cells, enable the study of the highly regulated process of human brain development in vitro. In vivo, the process is shaped by strict time- and ...