IN the skin of mice painted with chemical carcinogens a remarkable accumulation of mast cells is usually observed in the altered dermis. Cramer and Simpson 1 first observed that the accumulating mast ...

Mast cell stabilizers appear to have the potential to control IRRs and possibly allow for the safe reintroduction of agalsidase in patients with Fabry disease who previously received enzyme ...

This scanning electron microscopy image captures the moment where degranulating mast cells (pseudo-colored in sepia) attract and start to incorporate living neutrophils (pseudo-colored in cyan), ...

Certain immune cells backstab their cellular coworkers during allergic reactions. Mast cells, the security patrols of the immune system, can trigger allergic inflammation when they run into unfamiliar ...

Known for their role in allergic reactions, mast cells have long been recognised as key players in our immune system. When they encounter allergens, they release chemicals that trigger typical allergy ...

The function of mast cells, which are part of the immune system, is still a mystery. Scientists at the German Cancer Research Center (DKFZ) have now shown in mice: mast cells function as a sensor that ...

HISTAMINE release in anaphylaxis is inhibited by low oxygen tension in guinea pig lung 1–3 and with more difficulty in rat lung 4. Conversely, at normal oxygen tension, the anaphylactic reaction is ...

Although many topical or systemic antibiotics exist to treat acne vulgaris, the common inflammatory skin disease is not fully treatable. A new article published in The Journal of Clinical and ...