The researchers looked at a ubiquitin ligase enzyme named FBXL2, known to degrade proteins at various cellular membrane compartments. They found that by attaching or detaching a fat molecule or ...

By analyzing the sequences of the bacterial ligase enzymes, the team identified many other clusters of ligases likely involved in other peptide pathways.

Figure 1: Changes in primary sequence and 3D structure upon directed evolution of the hRXRα scaffold to the ligase enzyme 10C. Figure 3: Substrate-binding surface of ligase 10C probed by NMR and ...

A new study uncovers the intricate molecular mechanisms that regulate leaf senescence in apple plants, focusing on the crucial role of the E3 ligase enzyme, MdPUB23, and its interaction with the ...

Lab tests show that the enzyme (a type of RNA ligase, which connects two RNA molecules) functions like natural enzymes although its structure looks very different and it is flexible rather than rigid.

The drug attacks bacteria by inhibiting two separate enzymes (D-alanine racemase and D-alanine -- D-alanine ligase) each required to build and maintain the structural integrity of bacterial cell ...

Christian Behrend's lab at the Ludwig-Maximilians University (LMU), Munich, who are collaborators of the Bhogaraju Group, have also applied this method to TRAF6 – another E3 ligase and a ...

Phenylpropanoid pathway provides precursors for numerous secondary metabolites in plants. In this pathway, 4-coumarate-CoA ligase (EC 6.2.1.12, 4CL) is the main branch point enzyme which generates ...

The structure indicates that this artificially selected ribozyme uses reaction mechanisms that are much like those used by naturally occuring enzymes, Robertson said. “The L1 ligase appears to use ...