Knowing that naloxone works by stalling the µ-opioid receptor in an early, latent state suggests that molecules that can bind more tightly or more selectively to this form of the receptor could be ...

A drug called buprenorphine may be the best tool doctors have to fight the fentanyl crisis. Why hasn’t it been more widely adopted? A dose of buprenorphine, an opioid that can help treat addiction to ...

Opioid antagonists are medications people can take to treat opioid use disorder. They help by reducing withdrawal symptoms, addressing cravings, and managing overdoses. Doctors prescribe opioid ...

Narcan is just one brand of a drug called Naloxone, a drug used to help revive patients who are in mid-opioid overdose, essentially bringing them back from the brink of death. This tool is so useful ...

Nearly 1.5 million Americans were treated for addiction to prescription opioids or heroin in 2015, according to federal estimates, and when those people get seriously hurt or need surgery, it's often ...

A US study of more than a million Medicaid enrollees newly diagnosed with opioid use disorder (OUD), finds most—nearly seven ...

For patients recovering from opioid use disorder, particularly from drugs like fentanyl or heroin, the days immediately following a hospital stay are among the most dangerous. A new multi-state study ...

AstraZeneca has ended work on an opioid use disorder (OUD) drug after the orexin 1 receptor antagonist demonstrated a drug-drug interaction with an antifungal during a phase 2 trial. The Big Pharma ...