For the complement system to cause AMD, there must be initiation (a ‘trigger’), amplification, and local retinal damage caused by the process. The alternative pathway of the complement system is ...

The mammalian immune system is a remarkable complex of biochemical processes enabling efficient detection and prosecution of pathogens that threaten host viability. The incredible complexity of ...

We are studying the role of the complement system in kidneys and brains during health and disease. Traditionally, major complement proteins were shown to be generated by the liver and are functional ...

THE use of the complement-fixation test in serologic investigation serves as a frequent reminder to the physician of the existence of the complement system. It is probable that despite the advances ...

Global understanding of complement has shifted and developed since the 21st century: from our idea of a blood-based antibiotic system to a global regulator of immunity and tissue homeostasis. Recent ...

Traumatic brain injury (TBI) is a major cause of disability and a risk factor for early-onset dementia. The injury is characterized by a physical insult followed acutely by complement driven ...